For adults living with primary biliary cholangitis (PBC)
Let LIVDELZI take on your PBC
while you take in the moment
Ask your healthcare provider if LIVDELZI is right for you.
Is LIVDELZI right for me?
Find out if LIVDELZI could be the next step for your PBC.
Clinical trial results
See how LIVDELZI performed for people living with PBC.
Financial assistance
You could pay as little as $0 per month.† Restrictions apply.
People featured are compensated by Gilead.
Doctor actor portrayal.
*This information is an estimate derived from the use of information under license from the following IQVIA® information service: IQVIA LAAD, for the period of October 2024 through June 2025. IQVIA expressly reserves all rights, including rights of copying, distribution, and republication.
†Co-pay savings support is available for commercially insured eligible patients only. Additional restrictions apply. Subject to change; for full terms and conditions, visit www.mysupportpath.com/co-pay. This is not health insurance. Only accepted at participating pharmacies.
LAAD=Longitudinal Access Adjudication Data.
Watch the LIVDELZI commercial
LIVDELZI is the only treatment for adults with PBC to significantly improve key PBC lab results and itch
In the clinical trial, LIVDELZI:
Improved key
PBC lab results
in significantly more people compared with placebo at 1 year
Lowered alkaline phosphatase (ALP) to normal
at 1 year in significantly more people compared with placebo
Reduced
itch
starting at 1 month, with significant improvement seen at 6 months
Who participated in the clinical trial?
![Icon representing the LIVDELZI® (seladelpar) arm [or group]](-/media/affinity/livdelzipatient/icons/livdelzi-results/img-desktop-livdelzi-results-three-green-people.svg){kind=icon}
![Icon representing the placebo arm [or group]](-/media/affinity/livdelzipatient/icons/livdelzi-results/img-desktop-livdelzi-results-three-gray-people.svg){kind=icon}
What were the key goals and results of the clinical trial?
LIVDELZI was studied to see if it could help:
Improve key PBC lab results
LIVDELZI
vs
ursodiol alone
achieved the main trial goal of improving all 3 of these key PBC lab results at 12 months:
- Lowering ALP levels to less than 1.67x the top of the normal range
- Lowering ALP levels at least 15% from start of trial
- Achieving normal bilirubin levels
Lower ALP to normal
LIVDELZI
vs
ursodiol alone
achieved a secondary goal of the trial by achieving a normal ALP level at 12 months.
Reduce itch
lowered NRS
scores by
points
vs
lowered NRS
scores by
points
at 6 months for people who had an NRS score of ≥4 at the start of the trial, which was a secondary goal of the trial. Itch reduction was maintained from months 6 to 12. The NRS is a scale of 0 to 10 that measures itch severity, with 0 being no itch and 10 being the worst possible itch. The average NRS score at the start of the trial was 6.1 for LIVDELZI (49 people) and 6.6 for the placebo group (23 people).
The most common side effects for LIVDELZI in the clinical trial include headache, stomach (abdominal) pain, nausea, abdominal swelling (distension), and dizziness.
NRS=Numerical Rating Scale.
“Now that I’m taking LIVDELZI, I’m looking forward to seeing what this PBC treatment can do.”
Jennifer
Real LIVDELZI patient
Person featured is compensated by Gilead.
![Icon representing the LIVDELZI® (seladelpar) arm [or group]](/-/media/Affinity/LivdelziPatient/Icons/Common/icon-desktop-how-livdelzi-works-user.svg){kind=icon}
![Icon representing the LIVDELZI® (seladelpar) arm [or group]](/-/media/Affinity/LivdelziPatient/Icons/Common/icon-desktop-how-livdelzi-works-magnifying-glass.svg){kind=icon}
![Icon representing the LIVDELZI® (seladelpar) arm [or group]](/-/media/Affinity/LivdelziPatient/Icons/Common/icon-desktop-how-livdelzi-works-bottle.svg){kind=icon}
Tap for Important Safety Information, including serious side effects for bone fractures and changes in liver tests.
What is LIVDELZI?
LIVDELZI is a prescription medicine used to treat primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults who have not responded well to UDCA, or used alone in patients unable to tolerate UDCA.
LIVDELZI is not recommended for use in people who have advanced liver disease (decompensated cirrhosis). Symptoms of advanced liver disease may include confusion; having fluid in the stomach area (abdomen); black, tarry, or bloody stools; coughing up or vomiting blood; or having vomit that looks like “coffee grounds”.
It is not known if taking LIVDELZI will improve your chance of survival or prevent liver decompensation.
It is not known if LIVDELZI is safe and effective in children.
Important Safety Information
What are the possible side effects of LIVDELZI?
LIVDELZI can cause serious side effects, including:
- Bone fractures. Taking LIVDELZI may increase your risk of bone fractures. Tell your healthcare provider about any bone fractures, or if you develop pain, or have changes in your ability to move around.
- Changes in liver tests. Increased liver enzymes in the blood have happened when taking more LIVDELZI than prescribed. Your healthcare provider will do tests to check your liver before you start and during treatment with LIVDELZI.
Tell your healthcare provider right away if you have any of the following signs or symptoms of worsening liver problems during treatment with LIVDELZI:
- swelling of your stomach area (abdomen) from a build-up of fluid
- yellowing of your skin or the whites of your eyes
- pain on the right side of your stomach (abdomen)
- black, tarry, or bloody stools
- coughing up or vomiting blood, or your vomit looks like “coffee grounds”
- mental changes such as confusion, being sleepier than usual or harder to wake up, slurred speech, mood swings, or changes in personality
The most common side effects of LIVDELZI include headache, stomach (abdominal) pain, nausea, abdominal swelling (distension), and dizziness.
Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all the possible side effects of LIVDELZI.
What should I tell my healthcare provider before taking LIVDELZI?
Tell your healthcare provider about all of your medical conditions, including if you:
- have advanced liver disease.
- think you may have a blockage of the bile ducts in your liver (biliary obstruction).
- are pregnant or plan to become pregnant. It is not known if LIVDELZI will harm your unborn baby.
- Pregnancy safety study. If you become pregnant while taking LIVDELZI, tell your healthcare provider right away. There is a pregnancy safety study for women who take LIVDELZI during pregnancy. Talk to your healthcare provider about providing information to the LIVDELZI pregnancy safety study. The purpose of this pregnancy safety study is to capture information about your health and your baby’s health. You or your healthcare provider can report your pregnancy by calling 1-800-445-3235.
- are breastfeeding or plan to breastfeed. It is not known if LIVDELZI passes into your breast milk. Talk with your healthcare provider about the best way to feed your baby if you take LIVDELZI.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. LIVDELZI can affect the way certain medicines work. Certain other medicines may affect the way LIVDELZI works.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.
Please see Important Facts about LIVDELZI.